Last update: May 21st, 2020.
What is DxCOVID-19
DxCOVID-19 is an innovative test ―based on a routine blood test and an Artificial Intelligence (AI) algorithm―, that has been developed to help in early detection of SARS-CoV-2 (COVID-19) infection.
DxCOVID-19 demonstrated the feasibility and clinical soundness of using routine blood tests analysis ―such as Leukocytes, Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil, Platelet Count, C-Reactive Protein (CRP), Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT) or Serum Creatinine, among others―, and Machine Learning (ML) as an alternative to reverse transcription polymerase chain reaction (RT-PCR) tests and CT scans for identifying COVID-19 positive patients. This is especially useful as a quick and inexpensive screening test, which can be performed in the presence of any of the symptoms or signs related to a COVID-19 infection (such as fever, cough, shortness of breath, or sudden loss of smell or taste), but also in the case of fatigue, conjunctivitis, nausea, vomiting, abdominal discomfort or diarrhea, with which it is possible to reserve the RT-PCR tests ―more rare, laborious and expensive―, for those cases that the algorithm classifies as positive.
DxCOVID-19 is based on an algorithm that jointly processes clinical data of patients (sex, race/ethnicity and age), symptoms and signs (fever, cough, shortness of breath, sudden loss of smell or taste, fatigue, conjunctivitis, nausea, vomiting, abdominal discomfort or diarrhea), as well as several basic laboratory determinations, obtained in a simple and rapid blood test. It has been developed from data from real patients ―2,884 of them positive for SARS-CoV-2― all of them confirmed by RT-PCR. In this way, the performance achieved by DxCOVID-19 (sensitivity between 92% and 95%, and 65% especificity) provides enough proof that it can be used to discriminate among potential COVID-19 infectious patients with sufficient reliability, and similar sensitivity to the current gold standard, that is, the RT-PCR.
How does DxCOVID-19 work?
SARS-CoV-2 (COVID-19) infection creates a footprint in the blood that DxCOVID-19 can detect, since COVID-19 is associated with:
- Lymphopenia (abnormally low level of white blood cells in the blood).
- Thrombocytopenia (abnormally low level of platelets).
- Increased aspartate aminotransferase (AST) levels.
- Increased alanine aminotransferase (ALT) levels.
- Significantly increased C-Reactive Protein (CRP) levels.
In this way, DxCOVID-19 computes two different and independent algorithms: one exclusively with clinical data and laboratory results; and another, which also includes those symptoms and signs reported by the patients, creating two different scores.
Then, the algorithm generates a final score related to positivity and negativity by comparing the previous scores with the footprint already learned in the modeling process. If any of the symptoms and signs are not reported and the algorithm does not obtain a clear enough score, an indeterminate result may occur ―in this case, the algorithm performs several simulations for all the symptoms and signs, determining each of them as positive and negative, obtaining a score―.
Artificial Intelligence (AI) algorithm trained with real positive and negative SARS-CoV-2 patients and focused on enhancing doctor–patient relationship.
Based in Machine Learning (ML) and Deep Learning (DL) to develop powerful and accurate interpretative commenting through Natural Language Processing (NLP).
Only a swift visit to your preferred local laboratory or medical center to drawn the blood sample is required to generate the final report.
Complete list of several ―carefully selected―, blood analytes already bundled for an easy order.
Specially designed to be performed as many times should be required thanks to its high diagnostic capabilities and low price.
An easy-to-understand report with suggestions of further actions when a SARS-CoV-2 positive or negative is found specially written both for doctors and patients.
How the report looks like?
Once blood has been analyzed by you laboratory, our servers compute all values in an innovative algorithm and generate a final report with results, comments and suggestions.
Excerpt from a 6-page report*
* The report has been specially written to be interpreted by both doctors and patients.
Uses and purposes
Detect those SARS-CoV-2 positive cases to suggest a RT-PCR test to confirm positivity, and recommend isolation and/or medical treatment.
Discard those SARS-CoV-2 negative cases in order to don’t waste unnecessary and expensive RT-PCR tests.
Detect those positive results with a potential worst prognosis to allow quick interventions for better outcomes.
For whom is it intended?
Men and women with those symptoms and signs linked to COVID-19 ―mainly fever, cough, shortness of breath, sudden loss of smell or taste, but also fatigue, conjunctivitis, nausea, vomiting, abdominal discomfort or diarrhea―, that need to confirm or discard a potential SARS-CoV-2 infection for an early diagnosis.
Men and women without those symptoms and signs linked to COVID-19 who may have been in contact with a previous SARS-CoV-2 infected person, in order to confirm or discard any potential infection, since one of the biggest challenges in COVID-19 pandemic is asymptomatic transmission.
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